Two UCF-trained physicians 麻豆精品 S� who are dedicating their careers to addiction medicine and digestive health 麻豆精品 S� are receiving national attention for their discovery that an off-label medicine could help patients with alcohol-related liver disease.
Raj Shah and Richard Henriquez found that gabapentinoids, a family of drugs used to prevent seizures and commonly used for nerve pain, reduced alcohol withdrawal symptoms and slowed the progressions of liver disease better than another FDA-approved drug for alcohol use disorder.
Both physicians have been chief residents at the Orlando VA Medical Center during their Greater Orlando-Osceola Internal Medicine residency training sponsored by the UCF-HCA Healthcare 麻豆精品 S檚 Graduate Medical Education Consortium. Henriquez now serves as an attending physician at the VA, where he helps run the UCF residency and cares for patients. He plans to apply for board certification in addiction medicine this summer and is also a UCF undergraduate alum. Shah will graduate in June from UCF 麻豆精品 S檚 Internal Medicine of Greater Orlando 麻豆精品 S� Osceola residency and then join the consortium 麻豆精品 S檚 first Gastroenterology fellowship, where he will care for patients at the VA and HCA Florida Osceola Hospital.
Alcohol Misuse, Liver Disease Increasing
Nearly 30 million people in the United States 麻豆精品 S� ranging in age from 12 to adulthood 麻豆精品 S� have alcohol use disorder and that number is increasing. So is alcohol-related liver disease, which can lead to death, liver failure and transplantation, and other serious health ailments.
麻豆精品 S淎lcohol use disorder is a huge public health issue that needs to be brought to the forefront of research, 麻豆精品 S� Henriquez says. 麻豆精品 S淲e were looking for more ammunition to have in our toolbox and this study might open a path for it, 麻豆精品 S�
The research was presented recently during Digestive Disease Week in Washington D.C. The physicians used the VA 麻豆精品 S檚 extensive patient database to analyze about 49,000 patients who had been diagnosed with alcohol use disorder and were being treated with acamprosate, an FDA-approved drug for alcohol dependency, or gabapentin.
The physicians found that a statistically significant 15.8% of patients on Acamprosate advanced to severe liver disease, including scarring, cirrhosis, alcohol hepatitis or liver cancer, compared with 13.4% of the veterans taking gabapentin. For patients with pre-existing liver disease, 30.4% of those taking acamprosate saw their liver disease worsen, compared with 25.8% of those on gabapentin.
Acamprosate is only used for alcohol use disorder. Because gabapentinoids are used to treat pain from shingles and neuropathy (a common complication from diabetes), they are much more understood and prescribed by primary care physicians. Use of the drug tripled from 2002 to 2015 and it is one of the 10 most frequently prescribed medications nationwide, according to the study. The physician researchers hope that their findings will encourage more doctors to consider using gabapentinoids to treat patients with alcohol use dependency before they suffer significant liver damage. They point to statistics showing that only about 2.2% of alcohol-dependent patients use prescription drugs to help treat their addiction. One of the reasons, they say, is that patients must take two acamprosate pills three times a day and can suffer serious side effects if they drink alcohol while taking the drug.
Gabapentin treats pain by soothing the nervous system. As such, it may address mental health issues such as anxiety that can lead patients to drink heavily and subsequently damage their livers, Shah told media at the national conference.
麻豆精品 S淚f we 麻豆精品 S檙e able to, with gabapentin, kill two birds with one stone 麻豆精品 S� able to treat their pains as well as their alcohol use disorder 麻豆精品 S� then it 麻豆精品 S檚 warranted, using gabapentin versus just using acamprosate, 麻豆精品 S� he says.
Both researchers said more studies are needed to replicate their findings. They emphasize that physicians should not conclude that gabapentinoids are better than other FDA-approved drugs to treat alcohol use disorder, only that it is another option for patients and providers.
麻豆精品 S淓ach physician should review patients holistically at an individual level, considering their chronic medical problems and preferences while weighing the risks and benefits, 麻豆精品 S� Henriquez says.
How Research Impacts Patient Care
Both physicians said awareness is key to addressing alcohol use disorder and its serious damage to health.
麻豆精品 S淲hen education and risk awareness of the dangers of alcohol misuse goes up, usage tends to go down, 麻豆精品 S� Henriquez says. 麻豆精品 S淭hat 麻豆精品 S檚 why we need to put an emphasis on education and treatment. 麻豆精品 S�
Shah wants to become a gastroenterologist to help provide that care. He noted that lifestyle habits are increasing all forms of liver disease. One of the reasons UCF and HCA Healthcare created the new gastroenterology fellowship is to address a physician shortage in that specialty. Both physicians said they came to UCF for graduate medical education because the Internal Medicine program of Greater Orlando-Osceola offered a family-like atmosphere and emphasized research and other academic pursuits. The opportunity to care for veterans and residents of Osceola County, one of Florida 麻豆精品 S檚 fastest-growing and most complex communities, also allowed them to care for an incredible variety of patients and conditions.
Abdo Asmar has led the Internal Medicine Residency of Greater Orlando- Osceola since UCF 麻豆精品 S檚 inaugural program began in 2014. Today, the UCF-HCA Graduate Medical Education Consortium is one of the fastest growing in Florida, with more than 620 physicians training in 39 accredited programs this summer.
Asmar says Shah and Henriquez 麻豆精品 S檚 research shows their commitment to improving health for all.
麻豆精品 S淭hese physicians are difference makers, 麻豆精品 S� he says. 麻豆精品 S淎nd through their research, they are demonstrating a commitment to advancing science and patient care. With research, you go beyond the patient who is sitting in front of you. You improve care for patients you will never see. 麻豆精品 S�
