An immunity-boosting technology developed by the College of Medicine is being tested as a potential weapon in the fight against COVID-19.
UCF cancer researcher Alicja Copik created the therapy that stimulates the body 麻豆精品 S檚 natural killer (NK) cells with nanoparticles to increase their numbers and killing ability.聽 Kiadis Pharma, one of the world 麻豆精品 S檚 largest pharmaceutical companies, has licensed the technology and has it in clinical trials as a therapy for cancer. Now, with $9.5 million in funding from the Department of Defense and the Advanced Regenerative Manufacturing Institute 麻豆精品 S檚 (ARMI) BioFabUSA program 麻豆精品 S� which specializes in tissue engineering 麻豆精品 S� Kiadis has begun clinical trials using NK cell therapy as a potential treatment for COVID-19 patients with weakened immune systems. The study will also see if the therapy protects high-risk patients against respiratory infections like influenza, either alone or in combination with vaccines and antibodies.
麻豆精品 S淲e 麻豆精品 S檝e lost more than 200,000 Americans from this terrible disease and so there is a great need to develop innovative medicines,” says Robert Igarashi, Kiadis Pharma 麻豆精品 S檚 vice president of discovery and preclinical development and a former UCF faculty member. 聽 麻豆精品 S淲e know the body 麻豆精品 S檚 natural killer cells surveil and suppress the virally compromised cells, so then we considered the potential of our NK cells as a possible therapeutic for COVID-19. And in our current situation, nationally and internationally, what better time could there be to apply this because there are so many people in need of innovative medicines to fight this pandemic. 麻豆精品 S�
麻豆精品 S淲e 麻豆精品 S檝e lost more than 200,000 Americans from this terrible disease and so there is a great need to develop innovative medicines. 麻豆精品 S� 聽– Robert Igarashi, Kiadis Pharma 麻豆精品 S檚 vice president of discovery and preclinical development
麻豆精品 S淭he NK cells are like the immune system 麻豆精品 S檚 assassins, 麻豆精品 S� she says. 麻豆精品 S淲ith our technology, we supercharge them with nanoparticles to not only increase their numbers but we make them deploy with bigger and heavier guns to better target and kill the bad guys which are invaders like viruses and tumor cells. 麻豆精品 S�
Igarashi was a part of Copik 麻豆精品 S檚 team of researchers who developed the NK cell technology in 2016. The researchers later co-founded the company CytoSen to take the concept to market.聽In 2019, CytoSen was acquired by Netherlands-based Kiadis Pharma, which is now in clinical trials and hopes to see if the amplified NK cells have the ability to enhance a patient 麻豆精品 S檚 antiviral immunity against COVID-19 and other viruses that could cause pandemics.
Igarashi explains the vast majority of COVID-19 patients have lymphocytopenia, or a shortage of lymphocytes 麻豆精品 S� a type of white blood cell that helps protect the body from infection. The severity of the COVID-19 infection has been correlated to a reduction in the number of NK cells, a type of lymphocytes, in the body. The clinical trials are determining if injecting energized NK cells into ill patients can help them fight COVID-19.
Kiadis Pharma is working in partnership with the Abigail Wexner Research Institute at Nationwide Children 麻豆精品 S檚 Hospital in Columbus, Ohio. That institute received approval for an Investigational New Drug from the U.S. Food and Drug Administration to study the treatment of viral infections like COVID-19 with the NK cells therapeutic. Igarashi says the potential drug therapy is currently in phase one of clinical trials and could take several years before the drug is approved.
