{"id":118729,"date":"2021-03-25T10:23:00","date_gmt":"2021-03-25T14:23:00","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//news/news/wp-json/wp/v2/posts/118729//?p=118729"},"modified":"2021-06-14T09:20:40","modified_gmt":"2021-06-14T13:20:40","slug":"new-ucf-nanotech-gives-boost-to-detection-of-cancer-and-disease","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//news/news/wp-json/wp/v2/posts/118729//new-ucf-nanotech-gives-boost-to-detection-of-cancer-and-disease/news/wp-json/wp/v2/posts/118729//","title":{"rendered":"New UCF Nanotech Gives Boost to Detection of Cancer and Disease"},"content":{"rendered":"<p>Early screening can mean the difference between life and death in a cancer and disease diagnosis. That/news/wp-json/wp/v2/posts/118729/u2019s why <a href=/news/wp-json/wp/v2/posts/118729/"https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//research/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729/">University of Central Florida researchers</news/wp-json/wp/v2/posts/118729//a> are working to develop a new screening technique that/news/wp-json/wp/v2/posts/118729/u2019s more than 300 times as effective at detecting a biomarker for diseases like cancer than current methods.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>The technique, which was detailed recently in the <em>Journal of the American Chemical Society</news/wp-json/wp/v2/posts/118729//em>, uses nanoparticles with nickel-rich cores and platinum-rich shells to increase the sensitivity of an enzyme-linked immunosorbent assay (ELISA).</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>ELISA is a test that measures samples for biochemicals, such as antibodies and proteins, which can indicate the presence of cancer, HIV, pregnancy and more. When a biochemical is detected, the test generates a color output that can be used to quantify its concentration. The stronger the color is, the stronger the concentration. The tests must be sensitive to prevent false negatives that could delay treatment or interventions.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>In the study, the researchers found that when the nanoparticles were used in place of the conventional enzyme used in an ELISA /news/wp-json/wp/v2/posts/118729/u2014 peroxidase /news/wp-json/wp/v2/posts/118729/u2014 that the test was 300 times more sensitive at detecting carcinoembryonic antigen, a biomarker sometimes used to detect colorectal cancers.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<figure id=/news/wp-json/wp/v2/posts/118729/"attachment_110707/news/wp-json/wp/v2/posts/118729/" style=/news/wp-json/wp/v2/posts/118729/"max-width: 200px;/news/wp-json/wp/v2/posts/118729/" class=/news/wp-json/wp/v2/posts/118729/"figure float-right/news/wp-json/wp/v2/posts/118729/"><noscript><img decoding=/news/wp-json/wp/v2/posts/118729/"async/news/wp-json/wp/v2/posts/118729/" 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decoding=/news/wp-json/wp/v2/posts/118729/"async/news/wp-json/wp/v2/posts/118729/" width=/news/wp-json/wp/v2/posts/118729/"200/news/wp-json/wp/v2/posts/118729/" height=/news/wp-json/wp/v2/posts/118729/"300/news/wp-json/wp/v2/posts/118729/" class=/news/wp-json/wp/v2/posts/118729/"figure-img  img-fluid w-100 wp-image-110707 size-medium lazyload/news/wp-json/wp/v2/posts/118729/" src=/news/wp-json/wp/v2/posts/118729/"data:image/news/wp-json/wp/v2/posts/118729//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20200%20300%22%3E%3C%2Fsvg%3E/news/wp-json/wp/v2/posts/118729/" alt=/news/wp-json/wp/v2/posts/118729/"Xiaohu Xia/news/wp-json/wp/v2/posts/118729/" srcset=/news/wp-json/wp/v2/posts/118729/"data:image/news/wp-json/wp/v2/posts/118729//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20200%20300%22%3E%3C%2Fsvg%3E 200w/news/wp-json/wp/v2/posts/118729/" sizes=/news/wp-json/wp/v2/posts/118729/"(max-width: 200px) 100vw, 200px/news/wp-json/wp/v2/posts/118729/" data-srcset=/news/wp-json/wp/v2/posts/118729/"https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//wp-content/news/wp-json/wp/v2/posts/118729//blogs.dir/news/wp-json/wp/v2/posts/118729//20/news/wp-json/wp/v2/posts/118729//files/news/wp-json/wp/v2/posts/118729//2020/news/wp-json/wp/v2/posts/118729//06/news/wp-json/wp/v2/posts/118729//xiaohu_xia-6-24-2020_for_web-200x300.jpg 200w, https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//wp-content/news/wp-json/wp/v2/posts/118729//blogs.dir/news/wp-json/wp/v2/posts/118729//20/news/wp-json/wp/v2/posts/118729//files/news/wp-json/wp/v2/posts/118729//2020/news/wp-json/wp/v2/posts/118729//06/news/wp-json/wp/v2/posts/118729//xiaohu_xia-6-24-2020_for_web-533x800.jpg 533w, 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https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//wp-content/news/wp-json/wp/v2/posts/118729//blogs.dir/news/wp-json/wp/v2/posts/118729//20/news/wp-json/wp/v2/posts/118729//files/news/wp-json/wp/v2/posts/118729//2020/news/wp-json/wp/v2/posts/118729//06/news/wp-json/wp/v2/posts/118729//xiaohu_xia-6-24-2020_for_web-240x360.jpg 240w, https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//wp-content/news/wp-json/wp/v2/posts/118729//blogs.dir/news/wp-json/wp/v2/posts/118729//20/news/wp-json/wp/v2/posts/118729//files/news/wp-json/wp/v2/posts/118729//2020/news/wp-json/wp/v2/posts/118729//06/news/wp-json/wp/v2/posts/118729//xiaohu_xia-6-24-2020_for_web.jpg 800w/news/wp-json/wp/v2/posts/118729/" data-src=/news/wp-json/wp/v2/posts/118729/"https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//news/news/wp-json/wp/v2/posts/118729//wp-content/news/wp-json/wp/v2/posts/118729//blogs.dir/news/wp-json/wp/v2/posts/118729//20/news/wp-json/wp/v2/posts/118729//files/news/wp-json/wp/v2/posts/118729//2020/news/wp-json/wp/v2/posts/118729//06/news/wp-json/wp/v2/posts/118729//xiaohu_xia-6-24-2020_for_web-200x300.jpg/news/wp-json/wp/v2/posts/118729/"><figcaption class=/news/wp-json/wp/v2/posts/118729/"figure-caption/news/wp-json/wp/v2/posts/118729/">Xiaohu Xia, an assistant professor in UCF/news/wp-json/wp/v2/posts/118729/u2019s Department of Chemistry, is the co-author of a new study detailing a technique to improve cancer and disease detection.</news/wp-json/wp/v2/posts/118729//figcaption></news/wp-json/wp/v2/posts/118729//figure>/news/wp-json/wp/v2/posts/118729/n<p>And while a biomarker for colorectal cancer was used in the study, the technique could be used to detect biomarkers for other types of cancers and diseases, says Xiaohu Xia, an assistant professor in UCF/news/wp-json/wp/v2/posts/118729/u2019s <a href=/news/wp-json/wp/v2/posts/118729/"https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//sciences.ucf.edu/news/wp-json/wp/v2/posts/118729//chemistry/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729/">Department of Chemistry</news/wp-json/wp/v2/posts/118729//a> and study co-author.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>Colorectal cancer is the third leading cause of cancer-related deaths in the U.S., not counting some kinds of skin cancer, and early detection helps improve treatment outcomes, according to the U.S. Centers for Disease Control and Prevention.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>The increase in sensitivity comes from nickel-platinum nanoparticle /news/wp-json/wp/v2/posts/118729/u201cmimics/news/wp-json/wp/v2/posts/118729/u201d that greatly increase the reaction efficiency of the test, which increases its color output, and thus its detection ability, Xia says.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>Peroxidases found in the horseradish root have been widely used to generate color in diagnostic tests for decades. However, they have limited reaction efficiency and thus color output, which has inhibited the development of sensitive diagnostic tests, Xia says.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>Nanoparticle /news/wp-json/wp/v2/posts/118729/u201cmimics/news/wp-json/wp/v2/posts/118729/u201d of peroxidase have been extensively developed over the past 10 years, but none have achieved the reaction efficiency of the nanoparticles developed by Xia and his team.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>/news/wp-json/wp/v2/posts/118729/u201cThis work sets the record for the catalytic efficiency of peroxidase mimic,/news/wp-json/wp/v2/posts/118729/u201d Xia says. /news/wp-json/wp/v2/posts/118729/u201cIt breaks through the limitation of catalytic efficiency of peroxidase mimics, which is a long-standing challenge in the field./news/wp-json/wp/v2/posts/118729/u201d</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>/news/wp-json/wp/v2/posts/118729/u201cSuch a breakthrough enables highly sensitive detection of cancer biomarkers with the ultimate goal of saving lives through earlier detection of cancers,/news/wp-json/wp/v2/posts/118729/u201d he says.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>Xia says next steps for the research are to continue to refine the technology and apply it to clinical samples of human patients to study its performance.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>/news/wp-json/wp/v2/posts/118729/u201cWe hope the technology can be eventually used in clinical diagnostic laboratories in the near future,/news/wp-json/wp/v2/posts/118729/u201d Xia says.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>Study co-authors were Zheng Xi with UCF/news/wp-json/wp/v2/posts/118729/u2019s Department of Chemistry; Kecheng Wei and Shouheng Sun with Brown University; Qingxiao Wang and Moon J. Kim with the University of Texas at Dallas; and Victor Fung with Oak Ridge National Laboratory.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n<p>Xia joined UCF/news/wp-json/wp/v2/posts/118729/u2019s Department of Chemistry, part of UCF/news/wp-json/wp/v2/posts/118729/u2019s&nbsp;<a href=/news/wp-json/wp/v2/posts/118729/"https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.ucf.edu/news/wp-json/wp/v2/posts/118729//college/news/wp-json/wp/v2/posts/118729//sciences/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729/">College of Sciences</news/wp-json/wp/v2/posts/118729//a>, in 2018. He has a joint appointment in UCF/news/wp-json/wp/v2/posts/118729/u2019s&nbsp;<a href=/news/wp-json/wp/v2/posts/118729/"https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//www.nanoscience.ucf.edu/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729/">NanoScience Technology Center</news/wp-json/wp/v2/posts/118729//a>. Prior to his appointment at UCF, he worked at Michigan Technological University as an assistant professor and at Georgia Institute of Technology as a postdoctoral researcher. He has published more than 60 journal articles and received multiple research grants.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n","protected":false},"excerpt":{"rendered":"<p>The technique uses nickel-platinum nanoparticles to increase the sensitivity of an enzyme-linked immunosorbent assay, or ELISA, that is used to test for the presence of cancers, HIV and more.</news/wp-json/wp/v2/posts/118729//p>/news/wp-json/wp/v2/posts/118729/n","protected":false},"author":66,"featured_media":118738,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,23,24],"tags":[838,982,13545,3279,3280],"tu_author":[],"class_list":["post-118729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-research","category-science-technology","tag-chemistry","tag-college-of-sciences","tag-department-of-chemistry","tag-nanoscience-technology-center","tag-nanotechnology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.7) - https:/news/wp-json/wp/v2/posts/118729///news/wp-json/wp/v2/posts/118729//yoast.com/news/wp-json/wp/v2/posts/118729//product/news/wp-json/wp/v2/posts/118729//yoast-seo-premium-wordpress/news/wp-json/wp/v2/posts/118729// -->/news/wp-json/wp/v2/posts/118729/n<title>New UCF Nanotech Gives Boost to Detection of Cancer and Disease | University of Central Florida News</news/wp-json/wp/v2/posts/118729//title>/news/wp-json/wp/v2/posts/118729/n<meta name=/news/wp-json/wp/v2/posts/118729/"description/news/wp-json/wp/v2/posts/118729/" content=/news/wp-json/wp/v2/posts/118729/"The technique uses nickel-platinum nanoparticles to increase the sensitivity of an enzyme-linked immunosorbent assay, or ELISA, that is used to test for the presence of cancers, HIV and more./news/wp-json/wp/v2/posts/118729/" /news/wp-json/wp/v2/posts/118729//>/news/wp-json/wp/v2/posts/118729/n<meta name=/news/wp-json/wp/v2/posts/118729/"robots/news/wp-json/wp/v2/posts/118729/" 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